Coricidin HBP Cold & Flu

Generic Name: acetaminophen and chlorpheniramine (a SEET a MIN oh fen and KLOR fen IR a meen)

Brand Names: Coricidin, Coricidin HBP Cold & Flu

What is Coricidin HBP Cold & Flu (acetaminophen and chlorpheniramine)?

Acetaminophen is a pain reliever and a fever reducer.

Chlorpheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

The combination of acetaminophen and chlorpheniramine is used to treat runny nose, sneezing, watery eyes, and pain or fever caused by allergies, the common cold, or the flu.

Acetaminophen and chlorpheniramine may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Coricidin HBP Cold & Flu (acetaminophen and chlorpheniramine)?

Do not take this medication without a doctor's advice if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You may not be able to take medicine that contains acetaminophen. Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death. Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP. Avoid drinking alcohol. It may increase your risk of liver damage while taking acetaminophen. Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

What should I discuss with my healthcare provider before taking Coricidin HBP Cold & Flu (acetaminophen and chlorpheniramine)?

Do not take this medication if you are allergic to acetaminophen, chlorpheniramine, or any antihistamine. Do not take this medication without a doctor's advice if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You may not be able to take medicine that contains acetaminophen.

Ask a doctor or pharmacist about using acetaminophen and chlorpheniramine if you have:

• 
  

  liver disease;

  
  


• 
  

  glaucoma;

  
  


• 
  

  kidney disease;

  
  


• 
  

  an enlarged prostate;

  
  


• 
  

  problems with urination; or

  
  


• 
  

  a history of alcoholism.

  
  

It is not known whether acetaminophen and chlorpheniramine will harm an unborn baby. Before taking this medication, tell your doctor if you are pregnant. It is not known whether acetaminophen and chlorpheniramine passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take Coricidin HBP Cold & Flu (acetaminophen and chlorpheniramine)?

Use this medication exactly as directed on the label, or as prescribed by your doctor. Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death.

One Coricidin tablet contains 325 mg of acetaminophen. Know the amount of acetaminophen in the specific product you are taking.

Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Take with food or milk if this medicine upsets your stomach.

This medication can cause unusual results with allergy skin tests. Tell any doctor who treats you that you are taking an antihistamine.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness. Later symptoms may include pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes.

What should I avoid while taking Coricidin HBP Cold & Flu (acetaminophen and chlorpheniramine)?

Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP. Avoid drinking alcohol. It may increase your risk of liver damage while taking acetaminophen. This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Coricidin HBP Cold & Flu (acetaminophen and chlorpheniramine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have a serious side effect such as:

• 
  

  black, bloody, or tarry stools;

  
  


• 
  

  coughing up blood or vomit that looks like coffee grounds;

  
  


• 
  

  fast, pounding, or uneven heartbeats;

  
  


• 
  

  confusion, hallucinations, unusual thoughts or behavior;

  
  


• 
  

  severe dizziness, anxiety, restless feeling, or nervousness;

  
  


• 
  

  urinating less than usual or not at all;

  
  


• 
  

  easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms; or

  
  


• 
  

  nausea, pain in your upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

  
  

Less serious side effects may include:

• 
  

  dryness of the eyes, nose, and mouth;

  
  


• 
  

  blurred vision;

  
  


• 
  

  difficulty urinating;

  
  


• 
  

  dizziness, drowsiness;

  
  


• 
  

  problems with memory or concentration;

  
  


• 
  

  ringing in your ears;

  
  


• 
  

  feeling restless or excited (especially in children); or

  
  


• 
  

  mild nausea, stomach pain, constipation.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Coricidin HBP Cold & Flu (acetaminophen and chlorpheniramine)?

Cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by chlorpheniramine. Tell your doctor if you regularly use any of these other medicines.

Tell your doctor about all other medications you use, especially:

• 
  

  isoniazid;

  
  


• 
  

  zidovudine (Retrovir, AZT);

  
  


• 
  

  an antidepressant;

  
  


• 
  

  a diuretic (water pill);

  
  


• 
  

  probenecid (Benemid);

  
  


• 
  

  medication to treat irritable bowel syndrome;

  
  


• 
  

  bladder or urinary medications such as oxybutynin (Ditropan, Oxytrol) or tolterodine (Detrol);

  
  


• 
  

  aspirin or salicylates (such as Disalcid, Doan's Pills, Dolobid, Salflex, Tricosal, and others); or

  
  


• 
  

  seizure medication such as phenytoin (Dilantin) or phenobarbital (Luminal, Solfoton).

  
  

This list is not complete and other drugs may interact with acetaminophen and chlorpheniramine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Coricidin HBP Cold & Flu resources

• Coricidin HBP Cold & Flu Side Effects (in more detail)
• Coricidin HBP Cold & Flu Use in Pregnancy & Breastfeeding
• Drug Images
• Coricidin HBP Cold & Flu Drug Interactions
• Coricidin HBP Cold & Flu Support Group
• 2 Reviews for Coricidin HBP Cold & Flu - Add your own review/rating

• Coricidin Consumer Overview

Compare Coricidin HBP Cold & Flu with other medications

• Cold Symptoms
• Hay Fever
• Influenza
• Rhinorrhea

Where can I get more information?

• Your pharmacist can provide more information about acetaminophen and chlorpheniramine.

See also: Coricidin HBP Cold & Flu side effects (in more detail)

Chlorpromazine Tablets

Pronunciation: klor-PROE-ma-zeen
Generic Name: Chlorpromazine
Brand Name: Thorazine

Chlorpromazine is an antipsychotic. It may increase the risk of death when used to treat mental problems caused by dementia in elderly patients. Most of the deaths were linked to heart problems or infection. Chlorpromazine is not approved to treat mental problems caused by dementia. Discuss any questions or concerns with your doctor.

Chlorpromazine is used for:

Treating certain mental or mood disorders (eg, schizophrenia), the manic phase of manic-depressive disorder, anxiety and restlessness before surgery, the blood disease porphyria, severe behavioral and conduct disorders in children, nausea and vomiting, and severe hiccups. It is also used with other medicines to treat symptoms associated with tetanus. It may also be used for other conditions as determined by your doctor.

Chlorpromazine is a phenothiazine. It is not known exactly how it works.

Do NOT use Chlorpromazine if:

• you are allergic to any ingredient in Chlorpromazine or to other phenothiazines (eg, thioridazine)


• you have severe drowsiness


• you have recently taken large amounts of alcohol or medicines that may cause drowsiness, such as barbiturates (eg, phenobarbital) or narcotic pain medicines (eg, codeine)


• you are also taking amiodarone, bretylium, astemizole, cabergoline, cisapride, dofetilide, metoclopramide, pergolide, quinidine, sotalol, terfenadine, or tramadol

Contact your doctor or health care provider right away if any of these apply to you.

Before using Chlorpromazine:

Some medical conditions may interact with Chlorpromazine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have developed severe side effects (eg, blood problems, yellowing of the skin or eyes) while taking another phenothiazine (eg, thioridazine)


• if you have a history of heart problems (eg, angina, mitral valve problems), high or low blood pressure, blood problems (eg, anemia), bone marrow problems (eg, low white blood cell count), diabetes, liver problems (eg, cirrhosis), kidney problems, neuroleptic malignant syndrome (NMS), tardive dyskinesia (TD), an enlarged prostate gland, seizures, trouble urinating, mental or mood problems (eg, depression), or an adrenal gland tumor (pheochromocytoma)


• if you have asthma, a lung infection, or other lung or breathing problems (eg, emphysema); or increased pressure in the eyes or glaucoma, or if you are at risk of glaucoma


• if you have Alzheimer disease, dementia, Parkinson disease, or Reye syndrome


• if you have had high blood prolactin levels or a history of certain types of cancer (eg, breast, pancreas, pituitary, brain), or if you are at risk of breast cancer


• if you are in poor health or are regularly exposed to extreme heat or certain insecticides (organophosphorus insecticides)


• if you have a history of alcohol abuse, drink alcohol, or are in alcohol withdrawal


• if you will be having or have recently had a myelogram (x-ray of the spinal cord)


• if you take any medicine that may increase the risk of a certain type of irregular heartbeat (prolonged QT interval). Check with your doctor or pharmacist if you are unsure if any of your medicines may increase the risk of this type of irregular heartbeat

Some MEDICINES MAY INTERACT with Chlorpromazine. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Many prescription and nonprescription medicines (eg, used for allergies, blood clotting problems, cancer, infections, inflammation, aches and pains, heart problems, high blood pressure, high cholesterol, irregular heartbeat, mental or mood problems, nausea or vomiting, Parkinson disease, seizures, stomach or bowel problems, overactive bladder), multivitamin products, and herbal or dietary supplements (eg, herbal teas, coenzyme Q10, garlic, ginseng, gingko, St. John's wort) may interact with Chlorpromazine. Ask your doctor if you are unsure if any of your medicines may interact with Chlorpromazine.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Chlorpromazine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Chlorpromazine:

Use Chlorpromazine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Chlorpromazine by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.


• If you miss a dose of Chlorpromazine and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Chlorpromazine.

Important safety information:

• Chlorpromazine may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Chlorpromazine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Do NOT take more than the recommended dose without checking with your doctor.


• Do not drink alcohol while you are using Chlorpromazine.


• Check with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Chlorpromazine; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.


• Chlorpromazine may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.


• Do not become overheated in hot weather or while you are being active; heatstroke may occur.


• Chlorpromazine may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Chlorpromazine. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.


• Chlorpromazine may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.


• Some patients who take Chlorpromazine may develop muscle movements that they cannot control. This is more likely to happen in elderly patients, especially women. The chance that this will happen or that it will become permanent is greater in those who take Chlorpromazine in higher doses or for a long time. Muscle problems may also occur after short-term treatment with low doses. Tell your doctor at once if you have muscle problems with your arms; legs; or your tongue, face, mouth, or jaw (eg, tongue sticking out, puffing of cheeks, mouth puckering, chewing movements) while taking Chlorpromazine.


• Neuroleptic malignant syndrome (NMS) is a possibly fatal syndrome that can be caused by Chlorpromazine. Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms.


• Tell your doctor or dentist that you take Chlorpromazine before you receive any medical or dental care, emergency care, or surgery.


• Chlorpromazine may increase the amount of a certain hormone (prolactin) in your blood. Symptoms may include enlarged breasts, missed menstrual period, decreased sexual ability, or nipple discharge. Contact your doctor right away if you experience any of these symptoms.


• Chlorpromazine may raise or lower your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your vision change; give you a headache, chills, or tremors; or make you hungrier. If these symptoms occur, tell your doctor right away.


• Diabetes patients - Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.


• Chlorpromazine may cause the results of some pregnancy tests to be wrong. Check with your doctor if you have questions or concerns about your pregnancy test results.


• Chlorpromazine may interfere with certain lab tests, including phenylketonuria (PKU) tests. Be sure your doctor and lab personnel know you are taking Chlorpromazine.


• Lab tests, including liver and kidney function tests, complete blood cell counts, and eye exams, may be performed while you use Chlorpromazine. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Chlorpromazine with caution in the ELDERLY; they may be more sensitive to its effects, especially confusion; dizziness or light-headedness, especially upon standing; drowsiness; fainting; trouble urinating; uncontrolled muscle movements; and constipation.


• Chlorpromazine should not be used in CHILDREN younger than 6 months old; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Chlorpromazine while you are pregnant. Using Chlorpromazine during the third trimester may result in uncontrolled muscle movements or withdrawal symptoms in the newborn. Discuss any questions or concerns with your doctor. Chlorpromazine is found in breast milk. Do not breast-feed while taking Chlorpromazine.

If you stop taking Chlorpromazine suddenly and you have been taking it regularly or in high doses, you may have WITHDRAWAL symptoms. These may include nausea, vomiting, dizziness, stomach upset, and tremors.

Possible side effects of Chlorpromazine:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Agitation; constipation; dizziness; drowsiness; dry mouth; enlarged pupils; jitteriness; nausea; stuffy nose.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest or throat; swelling of the mouth, face, lips, or tongue; unusual hoarseness; wheezing); chest pain; confusion; decreased coordination; drooling; fainting; fast, slow, or irregular heartbeat; mask-like face; muscle spasms of the face, neck, or back; muscle weakness; new or worsening mental or mood problems; numbness of an arm or leg; prolonged or painful erection; restlessness; seizures; severe or persistent constipation; severe or persistent dizziness, drowsiness, or headache; shuffling walk; sleeplessness; stiff or rigid muscles; sudden shortness of breath; swelling of the hands, ankles, or feet; symptoms of infection (eg, fever, chills, persistent sore throat); symptoms of liver problems (eg, yellowing of the skin or eyes; dark urine; pale stools; severe or persistent nausea, stomach pain, or loss of appetite); tremor; trouble urinating; twisting or twitching movements; uncontrolled muscle movements (eg, twitching of the face or tongue; loss of balance; uncontrolled movements of arms or legs; trouble speaking, breathing, or swallowing); unusual bruising or bleeding; unusual eye movements or inability to move eyes; unusual or excessive sweating; unusual tiredness or weakness; unusually pale skin; vision changes (eg, blurred vision).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Chlorpromazine side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include agitation; coma; confusion; difficulty breathing; fainting; fast, slow, or irregular heartbeat; loss of consciousness; muscle spasms or uncontrolled muscle movements; restlessness; seizures; severe constipation or stomach pain; severe drowsiness or dizziness; tremors; or trouble urinating.

Proper storage of Chlorpromazine:

Store Chlorpromazine at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a tightly closed container. Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Chlorpromazine out of the reach of children and away from pets.

General information:

• If you have any questions about Chlorpromazine, please talk with your doctor, pharmacist, or other health care provider.


• Chlorpromazine is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• If using Chlorpromazine for an extended period of time, obtain refills before your supply runs out.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Chlorpromazine. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Chlorpromazine resources

• Chlorpromazine Side Effects (in more detail)
• Chlorpromazine Dosage
• Chlorpromazine Use in Pregnancy & Breastfeeding
• Drug Images
• Chlorpromazine Drug Interactions
• Chlorpromazine Support Group
• 8 Reviews for Chlorpromazine - Add your own review/rating

Compare Chlorpromazine with other medications

• Hiccups
• Light Sedation
• Mania
• Nausea/Vomiting
• Opiate Withdrawal
• Porphyria
• Psychosis
• Schizophrenia
• Tetanus

cholecalciferol, genistein, and zinc chelazome

Generic Name: cholecalciferol, genistein, and zinc chelazome (KOE le kal SIF er ol, GEN i styne, and ZINK KEE la zome)

Brand names: Fosteum, Fosteum (obsolete)

What is cholecalciferol, genistein, and zinc chelazome?

Cholecalciferol is vitamin D3. Vitamin D is important for the absorption of calcium from the stomach and for the functioning of calcium in the body.

Genistein is an isoflavone derived from a plant source. Genistein reduces cells that break down bone and stimulates cells that build bone in the body. It also reverses the bone effects of estrogen loss in postmenopausal women. Genistein also works with zinc to promote bone mineralization, which hardens and strengthens bone tissue.

Zinc is a naturally occurring mineral. Zinc is important for growth and for the development and health of body tissues.

The combination of cholecalciferol, genistein, and zinc chelazome is a medical food product. It is used to slow the metabolic processes that cause bone loss and may lead to osteoporosis.

Cholecalciferol, genistein, and zinc chelazome may be used for other purposes not listed in this medication guide.

What is the most important information I should know about cholecalciferol, genistein, and zinc chelazome?

You should not use this medication if you are allergic to cholecalciferol, genistein, or zinc chelazome, or if you have ever had cancer of the breast, cervix, uterus, or ovary.

Before you take cholecalciferol, genistein, and zinc chelazome, tell your doctor if you have liver disease, a gallbladder disorder, a blood cell cancer such as leukemia or lymphoma, sarcoidosis (an autoimmune disorder), an electrolyte imbalance, or any condition that makes it hard for your body to absorb nutrients from food (malabsorption).

Use this medication exactly as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended. An overdose of cholecalciferol or zinc can cause serious side effects. Do not take other vitamin or mineral supplements unless your doctor has told you to. Before using this medication, tell your doctor if you are pregnant or breast-feeding. Cholecalciferol, genistein, and zinc is not for use in children.

What should I discuss with my health care provider before taking cholecalciferol, genistein, and zinc chelazome?

You should not use this medication if you are allergic to cholecalciferol, genistein, or zinc chelazome, or if you have ever had cancer of the breast, cervix, uterus, or ovary.

If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication. Before you take cholecalciferol, genistein, and zinc chelazome, tell your doctor if you have:

• 
  

  liver disease;

  
  


• 
  

  a gallbladder disorder;

  
  


• 
  

  a blood cell cancer such as leukemia or lymphoma;

  
  


• 
  

  sarcoidosis (an autoimmune disorder);

  
  


• 
  

  an electrolyte imbalance; or

  
  


• 
  

  any condition that makes it hard for your body to absorb nutrients from food (malabsorption).

  
  

It is not known whether using cholecalciferol, genistein, and zinc during pregnancy is harmful to an unborn baby. Before using this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether this medication passes into breast milk or if it could harm a nursing baby. Do not use cholecalciferol, genistein, and zinc without telling your doctor if you are breast-feeding a baby. Cholecalciferol, genistein, and zinc is not for use in children.

How should I take cholecalciferol, genistein, and zinc chelazome?

Use this medication exactly as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Take this medication with water or another liquid.

Cholecalciferol, genistein, and zinc chelazome is usually taken twice daily, spaced 12 hours apart. Follow your doctor's instructions.

You may take cholecalciferol, genistein, and zinc chelazome with or without food. Take it with food if it upsets your stomach.

To be sure this medication is helping your condition, your blood and urine may need to be tested on a regular basis. Do not miss any scheduled appointments.

Cholecalciferol, genistein, and zinc chelazome is only part of a complete program of treatment that may also include diet, exercise, and calcium or other mineral supplementation. Follow your diet, medication, and exercise routines very closely.

Store cholecalciferol, genistein, and zinc chelazome at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of cholecalciferol or zinc can cause serious side effects.

Overdose symptoms may include headache, weakness, drowsiness, dry mouth, increased thirst, muscle weakness, confusion, feeling tired or restless, nausea, vomiting, increased urination, constipation, muscle or bone pain, metallic taste in the mouth, loss of appetite, weight loss, itchy skin, changes in heart rate, unusual thoughts or behavior, problems with speech or balance, or severe pain in your upper stomach spreading to your back.

What should I avoid while taking cholecalciferol, genistein, and zinc chelazome?

Avoid using food products that contain a fat substitute called olestra (Olean). Olestra can make it harder for your body to absorb cholecalciferol.

Do not take any vitamin or mineral supplements that your doctor has not recommended or prescribed for your condition.

Avoid using antacids without your doctor's advice. Use only the specific type of antacid your doctor recommends.

Cholecalciferol, genistein, and zinc chelazome side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have any of the overdose symptoms listed above in "What happens if I overdose?"

Less serious side effects are more likely to occur, such as:

• 
  

  stomach pain or upset;

  
  


• 
  

  vomiting; or

  
  


• 
  

  constipation.

  
  

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect cholecalciferol, genistein, and zinc chelazome?

The following drugs can interact with cholecalciferol, genistein, and zinc chelazome. Tell your doctor if you are using any of these:

• 
  

  cold medicine or throat lozenges that contain zinc;

  
  


• 
  

  cimetidine (Tagamet);

  
  


• 
  

  mineral oil;

  
  


• 
  

  orlistat (alli, Xenical);

  
  


• 
  

  seizure medication;

  
  


• 
  

  cholesterol-lowering medication such as cholestyramine (Prevalite, Questran), colesevelam (Welchol), colestipol (Colestid), eplerenone (Inspra), or spironolactone (Aldactazide, Aldactone); or

  
  


• 
  

  a diuretic (water pill) such as chlorothiazide (Diuril), hydrochlorothiazide (HCTZ, HydroDiuril, Hyzaar, Lopressor, Vasoretic, Zestoretic), chlorthalidone (Hygroton, Thalitone), indapamide (Lozol), metolazone (Mykrox, Zaroxolyn), and others.

  
  

This list is not complete and there may be other drugs that can interact with cholecalciferol, genistein, and zinc chelazome. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

More cholecalciferol, genistein, and zinc chelazome resources

• Cholecalciferol, genistein, and zinc chelazome Side Effects (in more detail)
• Cholecalciferol, genistein, and zinc chelazome Use in Pregnancy & Breastfeeding
• Cholecalciferol, genistein, and zinc chelazome Drug Interactions
• Cholecalciferol, genistein, and zinc chelazome Support Group
• 0 Reviews for Cholecalciferol, genistein, and zinc chelazome - Add your own review/rating

Compare cholecalciferol, genistein, and zinc chelazome with other medications

• Dietary Supplementation
• Osteopenia

Where can I get more information?

• Your pharmacist can provide more information about cholecalciferol, genistein, and zinc chelazome.

See also: cholecalciferol, genistein, and zinc chelazome side effects (in more detail)

Comvax

Generic Name: haemophilus b conjugate and hepatitis b vaccine (Intramuscular route)

hee-MOF-i-lus B KON-joo-gate VAX-een, hep-a-TYE-tis B VAX-een re-KOM-bin-ant

Commonly used brand name(s)

In the U.S.

• Comvax

Available Dosage Forms:

• Suspension

Therapeutic Class: Vaccine

Uses For Comvax

Haemophilus b conjugate vaccine and hepatitis B vaccine is a combination immunizing agent that is used to prevent infection caused by the Haemophilus influenzae type b (Hib) bacteria and hepatitis B virus. The vaccine works by causing your body to produce its own protection (antibodies) against the disease.

Infections with Haemophilus influenza type b (Hib) bacteria can cause life-threatening illnesses, such as meningitis (a brain disease), epiglottitis (a throat disease that can cause suffocation), pericarditis (a heart disease), pneumonia (a lung disease), and septic arthritis (a bone and joint disease). Hib meningitis may cause death or leave the child with serious and permanent damage, such as mental retardation, deafness, epilepsy, or partial blindness.

HBV infection is a major cause of serious liver diseases, such as hepatitis and cirrhosis, and a type of liver cancer called primary hepatocellular carcinoma.

Pregnant women who have hepatitis B infection or are carriers of hepatitis B virus can give the disease to their babies when they are born. These babies often suffer serious long-term illnesses from the disease.

Immunization against hepatitis B disease is recommended for all newborn babies, infants, and young children.

This vaccine is to be administered only by or under the direct supervision of your doctor.

Before Using Comvax

In deciding to use a vaccine, the risks of taking the vaccine must be weighed against the good it will do. This is a decision you and your doctor will make. For this vaccine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of Comvax® vaccine in infants younger than 6 weeks and older than 15 months of age. Safety and efficacy have not been established.

Geriatric

Comvax® vaccine is not recommended for adult or geriatric patients.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this vaccine. Make sure you tell your doctor if you have any other medical problems, especially:

• Allergy to yeast—Should not be used in patients with this condition.

• Bleeding problems (e.g., hemophilia, thrombocytopenia)—Use with caution. May have an increased risk of bleeding at the injection site.

• Severe illness with a fever—Your child's dose may need to be given at a later time.

• Weak immune system from a disease or medicine (e.g., those who are receiving a steroid, chemotherapy for cancer, or who have HIV infection)—May not work as well in patients with this condition.

Proper Use of Comvax

A nurse or other trained health professional will give your child this vaccine. This vaccine is given as a shot into one of your child's muscles, usually in the thighs.

This vaccine is usually given as 3 doses. It is usually given at 2, 4, and 12 to 15 months of age, unless your child's doctor tells you otherwise.

It is important that your child receive all of the doses of vaccine in this series. Try to keep all of your scheduled appointments. If your child does miss a dose of this vaccine, make another appointment as soon as possible.

Precautions While Using Comvax

It is very important that your child return to your doctor’s office at the right time for the second and third dose. Be sure to notify your child's doctor of any unwanted effects that occur after he or she receives the vaccine.

If your child develops a skin rash, hives, or any allergic reaction after receiving this vaccine, tell your child's doctor right away.

Tell your child's doctor right away if your child is allergic to latex rubber. The vaccine vials may contain dry natural latex rubber. This may cause an allergic reaction in patients who are sensitive to latex.

Before your child have any medical tests, tell the medical doctor in charge that your child is receiving this vaccine. The results of some tests may be affected by this vaccine.

This vaccine may not protect your child against diseases caused by haemophilus influenzae type b or hepatitis B infection if your child is already infected with the virus at the time he or she receives the shot.

Comvax Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

• Fever more than 103 degrees F

Less common

• Body aches or pain


• chills


• cough


• difficulty with breathing


• ear congestion


• fever


• headache


• loss of voice


• nasal congestion


• runny nose


• sneezing


• sore throat


• unusual tiredness or weakness

Incidence not known

• Black, tarry stools


• bleeding gums


• blistering, peeling, or loosening of the skin


• blood in the urine or stools


• convulsions


• diarrhea


• difficulty with swallowing


• dizziness


• fast heartbeat


• hives


• itching


• joint or muscle pain


• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs


• pinpoint red spots on the skin


• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue


• red, irritated eyes


• shortness of breath


• skin rash


• sores, ulcers, or white spots in the mouth or on the lips


• tightness in the chest


• unusual bleeding or bruising


• wheezing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Hard lumps, pain, redness, soreness, swelling, or warmth at the injection site


• irritability


• sleepiness or unusual drowsiness


• unusual, high-pitched crying

Less common

• Earache


• loss of appetite


• redness or swelling in the ear


• vomiting


• weight loss

Rare

• Sore mouth or tongue


• white patches in the mouth or throat or on the tongue


• white patches with diaper rash

Incidence not known

• Hives or welts


• redness of the skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Comvax side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Comvax resources

• Comvax Side Effects (in more detail)
• Comvax Use in Pregnancy & Breastfeeding
• Comvax Drug Interactions
• Comvax Support Group
• 0 Reviews for Comvax - Add your own review/rating

• Comvax Concise Consumer Information (Cerner Multum)


• Comvax Vaccine MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Comvax with other medications

• Haemophilus influenzae Prophylaxis
• Hepatitis B Prevention

Cardiotek-RX

Pronunciation: MUL-ti-VYE-ta-mins/FOE-lik AS-id/a-MEE-noe AS-ids
Generic Name: Multivitamins with Folic Acid/Amino Acids
Brand Name: Cardiotek-RX

Cardiotek-RX is used for:

Treating or preventing low levels of vitamins, folic acid, and amino acids in the body. It may also be used for other conditions as determined by your doctor.

Cardiotek-RX is a vitamin, folic acid, and amino acid supplement. It works by providing extra vitamins, folic acid, and amino acids to the body when you need more than what you get in your diet.

Do NOT use Cardiotek-RX if:

• you are allergic to any ingredient in Cardiotek-RX


• you have high blood levels of arginine (argininemia)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Cardiotek-RX:

Some medical conditions may interact with Cardiotek-RX. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have certain blood disorders (eg, pernicious anemia), kidney or liver problems, or urea cycle disorder


• if you have a history of herpes simplex virus infection

Some MEDICINES MAY INTERACT with Cardiotek-RX. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Fluorouracil because the risk of its side effects may be increased by Cardiotek-RX


• Hydantoins (eg, phenytoin) or levodopa because their effectiveness may be decreased by Cardiotek-RX

This may not be a complete list of all interactions that may occur. Ask your health care provider if Cardiotek-RX may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Cardiotek-RX:

• Use Cardiotek-RX as directed by your doctor. Check the label on the medicine for exact dosing instructions.


• Take Cardiotek-RX by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.


• Take Cardiotek-RX with a full glass of water (8 oz/240 mL).


• If you miss a dose of Cardiotek-RX, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Cardiotek-RX.

Important safety information:

• Do not take large doses of vitamins while you use Cardiotek-RX unless your doctor tells you to.


• Cardiotek-RX has folic acid in it. Before you start any medicine check the label to see if it has folic acid in it too. If it does not or if you are not sure, check with your doctor or pharmacist.


• PREGNANCY and BREAST-FEEDING: Cardiotek-RX is not indicated for use during pregnancy. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Cardiotek-RX while you are pregnant. It is not known if Cardiotek-RX is found in breast milk. Do not breast-feed while taking Cardiotek-RX.

Possible side effects of Cardiotek-RX:

All medicines may cause side effects, but many people have no, or minor, side effects. No COMMON side effects have been reported with Cardiotek-RX. Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Cardiotek-RX side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include diarrhea; nausea; stomach cramps; vomiting.

Proper storage of Cardiotek-RX:

Store Cardiotek-RX at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Cardiotek-RX out of the reach of children and away from pets.

General information:

• If you have any questions about Cardiotek-RX, please talk with your doctor, pharmacist, or other health care provider.


• Cardiotek-RX is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Cardiotek-RX. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Cardiotek-RX resources

• Cardiotek-RX Side Effects (in more detail)
• Cardiotek-RX Use in Pregnancy & Breastfeeding
• Cardiotek-RX Drug Interactions
• 0 Reviews for Cardiotek-RX - Add your own review/rating

• multivitamin Concise Consumer Information (Cerner Multum)


• Folplex Prescribing Information (FDA)


• Foltabs 800 Prescribing Information (FDA)


• Infuvite Pediatric Prescribing Information (FDA)


• Nephrocaps Prescribing Information (FDA)


• Nephrocaps


• Renal Caps Prescribing Information (FDA)


• Vitamin A Monograph (AHFS DI)

Compare Cardiotek-RX with other medications

• Dietary Supplementation

Cardizem Intravenous

Generic Name: diltiazem (Intravenous route)

dil-TYE-a-zem

Commonly used brand name(s)

In the U.S.

• Cardizem

Available Dosage Forms:

• Powder for Solution


• Solution

Therapeutic Class: Cardiovascular Agent

Pharmacologic Class: Calcium Channel Blocker

Chemical Class: Benzothiazepine

Uses For Cardizem

Diltiazem is used to control rapid heartbeats or abnormal heart rhythms. It belongs to a group of drugs called calcium channel blocking agents. Diltiazem affects the movement of calcium into the cells of the heart and blood vessels. As a result, the heart beats slower and the blood vessels relax, thus, increasing the supply of blood and oxygen to the heart while reducing its workload.

This medicine is available only with your doctor's prescription.

Before Using Cardizem

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of diltiazem in the pediatric population. Safety and efficacy have not been established.

Geriatric

No information is available on the relationship of age to the effects of diltiazem in geriatric patients. However, elderly patients are more likely to have age-related kidney or liver problems, which may require an adjustment in the dose for patients receiving diltiazem.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Cisapride

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acebutolol


• Alprenolol


• Amiodarone


• Aprepitant


• Atazanavir


• Atenolol


• Atorvastatin


• Betaxolol


• Bevantolol


• Bisoprolol


• Bucindolol


• Carteolol


• Carvedilol


• Celiprolol


• Clonidine


• Clozapine


• Colchicine


• Crizotinib


• Dantrolene


• Dilevalol


• Dronedarone


• Droperidol


• Erythromycin


• Esmolol


• Everolimus


• Fentanyl


• Labetalol


• Levobunolol


• Lurasidone


• Mepindolol


• Metipranolol


• Metoprolol


• Nadolol


• Nebivolol


• Oxprenolol


• Penbutolol


• Pindolol


• Propranolol


• Ranolazine


• Simvastatin


• Sotalol


• Talinolol


• Tertatolol


• Timolol


• Tolvaptan

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Alfentanil


• Alfuzosin


• Amlodipine


• Aspirin


• Buspirone


• Carbamazepine


• Celecoxib


• Cilostazol


• Cimetidine


• Clopidogrel


• Cyclosporine


• Dalfopristin


• Digitoxin


• Digoxin


• Dutasteride


• Efavirenz


• Enflurane


• Fosaprepitant


• Fosphenytoin


• Guggul


• Indinavir


• Lithium


• Lovastatin


• Methylprednisolone


• Midazolam


• Moricizine


• Nevirapine


• Nifedipine


• Phenytoin


• Quinupristin


• Rifampin


• Rifapentine


• Ritonavir


• Sirolimus


• St John's Wort


• Tacrolimus


• Triazolam

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Atrial fibrillation (type of abnormal heart rhythm) or


• Cardiogenic shock (shock caused by heart attack) or


• Heart block (type of abnormal heart rhythm, can use if have a pacemaker) or


• Severe hypotension (blood pressure too low) or


• Short PR syndrome (type of abnormal heart rhythm) or


• Sick sinus syndrome (type of abnormal heart rhythm, can use if have a pacemaker) or


• Ventricular tachycardia (type of abnormal heart rhythm) or


• Wolff-Parkinson-White syndrome (type of abnormal heart rhythm)—Should not use in patients with these conditions.

• Kidney disease or


• Liver disease or—Use with caution. The effects of this medicine may be increased because of slower removal from the body.

Proper Use of Cardizem

A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed into one of your veins.

Precautions While Using Cardizem

Your doctor will only give you a few doses of this medicine until your condition improves, and then you will be switched to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.

Cardizem Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

• Blurred vision


• confusion


• dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly


• sweating


• unusual tiredness or weakness

Less common

• Fast, slow, or irregular heartbeat

Rare

• Anxiety


• chest pain


• decreased urine output


• difficult or labored breathing


• dilated neck veins


• dry mouth


• extreme fatigue


• hyperventilation


• irregular breathing


• irritability


• joint pain, stiffness, or swelling


• lower back, side, or stomach pain


• nervousness


• no heartbeat


• palpitations


• restlessness


• shaking


• shortness of breath


• swelling of feet or lower legs


• tightness in chest


• trouble sleeping


• troubled breathing


• weight gain


• wheezing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

• Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site


• feeling of warmth or heat


• flushing or redness of the skin, especially on the face and neck


• headache

Rare

• Change in vision


• constipation


• impaired vision


• itching skin


• lack or loss of strength


• nausea


• vomiting

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Cardizem Intravenous resources

• Cardizem Intravenous Side Effects (in more detail)
• Cardizem Intravenous Use in Pregnancy & Breastfeeding
• Drug Images
• Cardizem Intravenous Drug Interactions
• Cardizem Intravenous Support Group
• 6 Reviews for Cardizem Intravenous - Add your own review/rating

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ClindaMax Gel

clindamycin phosphate

Dosage Form: gel
ClindaMax® Gel

(Clindamycin Phosphate Gel USP, 1%)

Rx only

FOR EXTERNAL USE ONLY

AVOID CONTACT WITH EYES

DESCRIPTION

ClindaMax® Gel (Clindamycin Phosphate Gel), for topical use, contains clindamycin phosphate, USP, at a concentration equivalent to 10 mg clindamycin per gram.

Clindamycin phosphate is a water soluble ester of the semi-synthetic antibiotic produced by a 7(S)-chloro-substitution of the 7(R)-hydroxyl group of the parent antibiotic lincomycin.

The gel contains allantoin, carbomer 934P, methylparaben, polyethylene glycol 400, propylene glycol, sodium hydroxide and purified water.

The structural formula is represented below:

The chemical name for clindamycin phosphate is Methyl 7 - chloro - 6,7,8 - trideoxy - 6 - (1 - methyl - trans - 4 - propyl - L - 2 - pyrrolidinecarboxamido) - 1 - thio - L - threo - (α) - D - galacto - octopyranoside 2-(dihydrogen phosphate).

CLINICAL PHARMACOLOGY

Although clindamycin phosphate is inactive in vitro, rapid in vivo hydrolysis converts this compound to the antibacterially active clindamycin.

Cross resistance has been demonstrated between clindamycin and lincomycin.

Antagonism has been demonstrated between clindamycin and erythromycin.

Following multiple topical applications of clindamycin phosphate at a concentration equivalent to 10 mg clindamycin per mL in an isopropyl alcohol and water solution, very low levels of clindamycin are present in the serum (0-3 ng/mL) and less than 0.2% of the dose is recovered in urine as clindamycin.

Clindamycin activity has been demonstrated in comedones from acne patients. The mean concentration of antibiotic activity in extracted comedones after application of Clindamycin Phosphate Topical Solution for 4 weeks was 597 mcg/g of comedonal material (range 0 - 1490). Clindamycin in vitro inhibits all Propionibacterium acnes cultures tested (MICs 0.4 mcg/mL). Free fatty acids on the skin surface have been decreased from approximately 14% to 2% following application of clindamycin.

INDICATIONS AND USAGE

ClindaMax® (Clindamycin Phosphate Gel) is indicated in the treatment of acne vulgaris. In view of the potential for diarrhea, bloody diarrhea and pseudomembranous colitis, the physician should consider whether other agents are more appropriate. (See CONTRAINDICATIONS,WARNINGS and ADVERSE REACTIONS.)

CONTRAINDICATIONS

ClindaMax® (Clindamycin Phosphate Gel) is contraindicated in individuals with a history of hypersensitivity to preparations containing clindamycin or lincomycin, a history of regional enteritis or ulcerative colitis, or a history of antibiotic-associated colitis.

WARNINGS

Orally and parenterally administered clindamycin has been associated with severe colitis which may result in patient death. Use of the topical formulation of clindamycin results in absorption of the antibiotic from the skin surface. Diarrhea, bloody diarrhea, and colitis (including pseudomembranous colitis) have been reported with the use of topical and systemic clindamycin.

Studies indicate a toxin(s) produced by clostridia is one primary cause of antibiotic-associated colitis. The colitis is usually characterized by severe persistent diarrhea and severe abdominal cramps and may be associated with the passage of blood and mucus. Endoscopic examination may reveal pseudomembranous colitis. Stool cultures for Clostridium difficile and stool assay for C. difficile toxin may be helpful diagnostically.

When significant diarrhea occurs, the drug should be discontinued. Large bowel endoscopy should be considered to establish a definitive diagnosis in cases of severe diarrhea.

Antiperistaltic agents such as opiates and diphenoxylate with atropine may prolong and/or worsen the condition. Vancomycin has been found to be effective in the treatment of antibiotic-associated pseudomembranous colitis produced by Clostridium difficile. The usual adult dosage is 500 mg to 2 grams of vancomycin orally per day in three to four divided doses administered for 7 to 10 days. Cholestyramine or colestipol resins bind vancomycin in vitro. If both a resin and vancomycin are to be administered concurrently, it may be advisable to separate the time of administration of each drug.

Diarrhea, colitis, and pseudomembranous colitis have been observed to begin up to several weeks following cessation of oral and parenteral therapy with clindamycin.

PRECAUTIONS

General: Clindamycin phosphate should be prescribed with caution in atopic individuals.

Drug Interactions: Clindamycin has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. Therefore it should be used with caution in patients receiving such agents.

Pregnancy:Teratogenic Effects–Pregnancy Category B. Reproduction studies have been performed in rats and mice using subcutaneous and oral doses of clindamycin ranging from 100 to 600 mg/kg/day and have revealed no evidence of impaired fertility or harm to the fetus due to clindamycin. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.

Nursing Mothers: It is not known whether clindamycin is excreted in human milk following use of clindamycin phosphate. However, orally and parenterally administered clindamycin has been reported to appear in breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Pediatric Use: Safety and effectiveness in pediatric patients under the age of 12 has not been established.

Adverse Reactions

In 18 clinical studies of various formulations of Clindamycin Phosphate using placebo vehicle and/or active comparator drugs as controls, patients experienced a number of treatment emergent adverse dermatologic events [see table below].

Number of patients reporting events

# not recorded
* of 126 subjects
Treatment Emergent Adverse Event	Solution	Gel	Lotion
	n=553 (%)	n=148 (%)	n=160 (%)
Burning	62 (11)	15 (10)	17 (11)
Itching	36 (7)	15 (10)	17 (11)
Burning/Itching	60 (11)	# (–)	# (–)
Dryness	105 (19)	34 (23)	29 (18)
Erythema	86 (16)	10 (7)	22 (14)
Oiliness/Oily Skin	8 (1)	26 (18)	12* (10)
Peeling	61 (11)	# (–)	11 (7)

Orally and parenterally administered clindamycin has been associated with severe colitis which may end fatally.

Cases of diarrhea, bloody diarrhea and colitis (including pseudomembranous colitis) have been reported as adverse reactions in patients treated with oral and parenteral formulations of clindamycin and rarely with topical clindamycin (see WARNINGS).

Abdominal pain and gastrointestinal disturbances as well as gram-negative folliculitis have also been reported in association with the use of topical formulations of clindamycin.

OVERDOSAGE

Topically applied clindamycin topical solution can be absorbed in sufficient amounts to produce systemic effects (see WARNINGS).

DOSAGE AND ADMINISTRATION

Apply a thin film of ClindaMax® (Clindamycin Phosphate Gel) twice daily to affected area.

Keep container tightly closed.

HOW SUPPLIED

ClindaMax® Gel (Clindamycin Phosphate Gel USP, 1%) containing clindamycin phosphate equivalent to 10 mg clindamycin per gram is available in the following sizes:

30 gram tube NDC 0462 - 0390 - 30                     60 gram tube NDC 0462-0390-60

Store at controlled room temperature 15°-30°C (59°-86°F). Protect from freezing.

January 2008

PharmaDerm®

A division of Nycomed US Inc.

Melville, NY 11747 USA

www.pharmaderm.com

I8390C

R1/08

PACKAGE LABEL – PRINCIPAL DISPLAY PANEL – 30 G LABEL

NDC 0462-0390-30

PharmaDerm ®

ClindaMax ® Gel

(clindamycin phosphate gel USP 1%)

equivalent to 1% clindamycin

For Topical Use Only FOR EXTERNAL USE ONLY AVOID CONTACT WITH EYES

Rx only

30 g

PACKAGE LABEL – PRINCIPAL DISPLAY PANEL – 30 G CARTON

NDC 0462-0390-30

PharmaDerm ®

ClindaMax ® Gel

(clindamycin phosphate gel USP 1%) equivalent to 1% clindamycin

For Topical Use Only FOR EXTERNAL USE ONLY AVOID CONTACT WITH EYES

Rx only

30 g

PACKAGE LABEL – PRINCIPAL DISPLAY PANEL – 60 G LABEL

NDC 0462-0390-60

PharmaDerm ®

ClindaMax ® Gel

(clindamycin phosphate gel USP 1%)

equivalent to 1% clindamycin

For Topical Use Only FOR EXTERNAL USE ONLY AVOID CONTACT WITH EYES

Rx only

60 g

PACKAGE LABEL – PRINCIPAL DISPLAY PANEL – 60 G CARTON

NDC 0462-0390-60

PharmaDerm ®

ClindaMax ® Gel

(clindamycin phosphate gel USP 1%) equivalent to 1% clindamycin

For Topical Use Only FOR EXTERNAL USE ONLY AVOID CONTACT WITH EYES

Rx only

60 g

CLINDAMAX  clindamycin phosphate  gel

Product Information Product Type HUMAN PRESCRIPTION DRUG NDC Product Code (Source) 0462-0390 Route of Administration TOPICAL DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength clindamycin phosphate (clindamycin) clindamycin phosphate 10 mg  in 1 g

Inactive Ingredients Ingredient Name Strength Water   Allantoin   Polyethylene Glycol 400   Propylene Glycol   Methylparaben   Sodium Hydroxide

Product Characteristics Color      Score      Shape Size Flavor Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 0462-0390-30 1 TUBE In 1 CARTON contains a TUBE 1 30 g In 1 TUBE This package is contained within the CARTON (0462-0390-30) 2 0462-0390-60 1 TUBE In 1 CARTON contains a TUBE 2 60 g In 1 TUBE This package is contained within the CARTON (0462-0390-60)

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
ANDA	ANDA064160	10/01/2009

Labeler -  PharmaDerm, A division of Nycomed US Inc. (043838424)

Registrant - Nycomed US Inc. (043838424)

Establishment
Name	Address	ID/FEI	Operations
Nycomed US Inc.		043838424	ANALYSIS

Establishment
Name	Address	ID/FEI	Operations
Nycomed US Inc.		174491316	MANUFACTURE

Revised: 10/2009 PharmaDerm, A division of Nycomed US Inc.

More ClindaMax Gel resources

• ClindaMax Gel Side Effects (in more detail)
• ClindaMax Gel Use in Pregnancy & Breastfeeding
• ClindaMax Gel Drug Interactions
• ClindaMax Gel Support Group
• 3 Reviews for ClindaMax - Add your own review/rating

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Cinryze

Generic Name: c1 esterase inhibitor, human (Intravenous route)

C1 ES-ter-ase in-HIB-i-ter, HUE-man

Commonly used brand name(s)

In the U.S.

• Berinert


• Cinryze

Available Dosage Forms:

• Powder for Solution

Uses For Cinryze

C1 esterase inhibitor is used to treat or prevent hereditary angioedema (HAE), which is a rare disease that causes swelling of the face, hands, feet, throat, stomach, bowels, or sexual organs. People who have HAE have low levels of C1 esterase inhibitor in their body. This medicine works by improving your immune system and clotting system.

This medicine is available only with your doctor's prescription.

Before Using Cinryze

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of C1 esterase inhibitor in children 12 years of age and younger. Safety and efficacy have not been established.

Geriatric

Appropriate studies have not been performed on the relationship of age to the effects of C1 esterase inhibitor in the geriatric population. Safety and efficacy have not been established.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Blood clots, history of—Use with caution. May make this condition worse.

Proper Use of c1 esterase inhibitor, human

This section provides information on the proper use of a number of products that contain c1 esterase inhibitor, human. It may not be specific to Cinryze. Please read with care.

A nurse or other trained health professional will give you or your child this medicine. This medicine is given through a needle placed in one of your veins.

This medicine may sometimes be given at home to patients who do not need to be in the hospital or clinic. If you are using this medicine at home, your doctor or nurse will teach you how to prepare and inject the medicine. Be sure that you understand how to use the medicine.

Make sure family members or other people you are with know how to inject the medicine in case you are unable to do it yourself during an HAE attack.

Use a new needle and syringe each time you inject your medicine.

Carry this medicine with you at all times for emergency use in case you have an HAE attack.

This medicine comes with a patient information leaflet. Read and follow the instructions in the insert carefully. Ask your doctor if you have any questions.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For injection dosage form:
  
  • For hereditary angioedema:
    
    • Adults and teenagers—Dose is based on body weight and must be determined by a doctor. The usual dose is 20 units per kilogram (kg) of body weight injected into a vein.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the injection kits at room temperature, away from heat, moisture, and direct light. Keep the medicine in the original carton until ready to use. You may store the vial of Berinert® powder in the refrigerator. Do not freeze.

You may store the mixed liquid at room temperature and use it within 8 hours. Do not refrigerate or freeze the mixed liquid.

Check the injection kits regularly to make sure that the powder or liquid has not changed its color. Do not use this medicine if the powder or liquid has changed its color, or if there are solids in the mixed liquid.

Do not reuse the remaining portion of the medicine that is left in the vial. Throw away the vial after you have used it.

Precautions While Using Cinryze

It is very important that your doctor check the progress of you or your child at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it.

HAE attack is a life-threatening reaction and requires immediate medical attention. Check with your doctor right away, or go to an emergency room as soon as possible, even if you feel better after using this medicine.

This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Call your doctor or nurse right away if you or your child have a rash; itching; hives; hoarseness; chest tightness; lightheadedness, dizziness, or fainting; wheezing; shortness of breath; trouble breathing; trouble swallowing; or any swelling of your hands, face, or mouth after you receive this medicine.

This medicine may increase your risk of developing blood clots. Check with your doctor right away if you or your child have swelling and pain in your arms, legs, or stomach; chest pain; shortness of breath; loss of sensation; confusion; or problems with muscle control or speech.

This medicine is made from donated human blood. Some human blood products have transmitted certain viruses to people who have received them. The risk of getting a virus from medicines made of human blood has been greatly reduced in recent years. This is the result of required testing of human donors for certain viruses, and testing during the manufacture of these medicines. Although the risk is low, talk with your doctor if you have concerns.

Cinryze Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

• Chest pain


• chills


• cough


• ear congestion or pain


• fever


• head congestion


• headache


• hoarseness or other voice changes


• nasal congestion


• pain or tenderness around the eyes and cheekbones


• rash


• runny nose


• shortness of breath or troubled breathing


• sneezing


• sore throat


• stuffy or runny nose


• tightness of the chest or wheezing

Incidence not known

• Dark urine


• difficulty with swallowing


• dizziness


• fast heartbeat


• general tiredness and weakness


• hives


• itching


• light-colored stools


• nausea and vomiting


• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue


• unusual tiredness or weakness


• upper right abdominal or stomach pain


• yellow eyes and skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Abdominal or stomach pain


• diarrhea


• muscle spasms


• pain

Less common

• Change in taste


• loss of taste

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Cinryze side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Cinryze resources

• Cinryze Side Effects (in more detail)
• Cinryze Use in Pregnancy & Breastfeeding
• Cinryze Support Group
• 3 Reviews for Cinryze - Add your own review/rating

• Cinryze Prescribing Information (FDA)


• Cinryze Monograph (AHFS DI)


• Cinryze MedFacts Consumer Leaflet (Wolters Kluwer)


• Cinryze Consumer Overview


• Berinert Prescribing Information (FDA)


• Berinert MedFacts Consumer Leaflet (Wolters Kluwer)


• Berinert Consumer Overview

Compare Cinryze with other medications

• Hereditary Angioedema